NFL MATCHUP REPORT

December 22, 2025, 8:15 | Lucas Oil Stadium

San Francisco 49ers (10-4) VS Indianapolis Colts (8-6)

ODDS

Bet365
5Dimes
BOL
bodog
pin
Moneyline


-255
211
-250
210

Spread


-6 105
6 -125
-5.5 -110
5.5 -110

Total
o
u
o
u
46 o -110
46 u -110
46.5 o -105
46.5 u -115
o
u

RECENT FORM

NameRecord ATSOffense DefenseDiff ATS HomeATS Away OU RecordOU Home OU Away
San Francisco 10-4 9-5 24.57 20.93 3.64 3-3 6-2 8-6 3-3 5-3
Indianapolis 8-6 8-6 28.00 21.64 6.36 4-3 4-3 7-7 4-3 3-4

POWER STATS

Yards Per Point

NameOffense DefenseDifferential
SF 14.14 15.94 -1.8
IND 12.77 15.84 -3.07

Yards Per Pass

NameOffense DefenseDifferential
SF 10.44 9.65 0.79
IND 10.76 10.44 0.32

Yards Per Rush

NameOffense DefenseDifferential
SF 3.51 4.33 -0.82
IND 4.84 3.74 1.1

SMART CHART

SF
NAME
IND
24.57
OFFENSE
28.00
20.93
DEFENSE
21.64
3.64
DIFFERENTIAL
6.36
246.14
PASSING YARDS
229.00
101.36
RUSH YARDS
128.50
227.57
PASSING YARDS ALLOWED
247.57
106.07
RUSHING YARDS ALLOWED
95.14
0.36
TURNOVER DIFFERENTIAL
-0.15

TEAM RECORDS

San Francisco 49ers

NameRecord HomeAway ATSATS Home ATS AwayOffense DefenseDiff
Overall 10-4 4-2 6-2 9-5 3-3 6-2 24.57 20.93 3.64
Last 3 3-0 2-0 1-0 3-0 2-0 1-0 27.67 13.67 14.00
vs Conf 8-2 3-1 5-1 7-3 2-2 5-1 12.60 11.50 1.10
vs Div 4-1 1-1 3-0 3-2 0-2 3-0 25.20 23.00 2.20

Indianapolis Colts

NameRecord HomeAway ATSATS Home ATS AwayOffense DefenseDiff
Overall 8-6 6-1 2-5 8-6 4-3 4-3 28.00 21.64 6.36
Last 3 0-3 0-1 0-2 1-2 0-1 1-1 17.00 24.67 -7.67
vs Conf 6-4 4-1 2-3 7-3 4-1 3-2 11.40 9.00 2.40
vs Div 2-2 1-1 1-1 2-2 1-1 1-1 28.50 22.50 6.00

SUPERGRID

TitleStat RankStat Rank
Away Team Overall Scoring vs Home Team Overall Defense 24.57 11 21.64 12
Away Team Road Passing vs Home Team Home Passing Defense 238.00 8 210.71 17
Away Team Road Rushing vs Home Team Home Rushing Defense 91.25 27 107.29 13
Home Team Overall Scoring vs Away Team Overall Defense 28.00 6 20.93 11
Home Team Home Passing vs Away Team Road Passing Defense 234.43 11 252.75 28
Home Team Home Rushing vs Away Team Road Rushing Defense 163.14 1 104.38 8

HEAD TO HEAD SUMMARY

TeamRecord ATSOU ScoreRush YPRPA CPPY TYTO +/-
San Francisco 2-6 2-6 4-4 19.50 112.25 4.91 33.62 59.85 195.88 308.12 2.25
Indianapolis 6-2 6-2 4-4 24.88 124.00 4.08 33.12 64.91 243.12 367.12 1.50

HEAD TO HEAD DETAIL

DateAway HomeScore LineTotal OU ResultARY APYATY ATTHRY HPYHTY HTTAway Team Attempts Home Team AttemptsAway Team Completions Home Team Completions
Oct 24, 2021 IND SF 30 - 18 -3.5 41.5 O 148 147 295 2 111 169 280 4 26 27 17 16
Oct 8, 2017 SF IND 23 - 26 -1.5 44 O 66 336 402 0 159 288 447 1 46 34 29 22
Sep 22, 2013 IND SF 27 - 7 -10.5 45.5 U 184 152 336 0 115 139 254 2 26 27 17 13
Nov 1, 2009 SF IND 14 - 18 -13 45.5 U 113 182 295 2 61 349 410 0 32 49 19 32
Oct 9, 2005 IND SF 28 - 3 16 45 U 120 245 365 3 133 44 177 5 31 23 23 9
Nov 25, 2001 SF IND 40 - 21 -2.5 52.5 O 171 169 340 1 127 364 491 5 22 51 14 31
Oct 18, 1998 IND SF 31 - 34 -18 45.5 O 105 231 336 0 127 321 448 2 30 51 18 33
Oct 15, 1995 SF IND 17 - 18 10 47.5 U 62 207 269 2 88 169 257 1 41 18 28 12
Sep 10, 1989 SF IND 30 - 24 3 42.5 O 0 0 0 0 0 0 0 0 0 0 0 0
Oct 5, 1986 IND SF 14 - 35 -17.5 40 O 0 0 0 0 0 0 0 0 0 0 0 0

BETTING ODDS TRENDS

Indianapolis Colts

Indianapolis is 2-4 ATS in its last 6 games
Indianapolis is 1-5 SU in its last 6 games
The total has gone UNDER in 4 of Indianapolis's last 6 games
Indianapolis is 8-1 SU in its last 9 games at home
The total has gone OVER in 17 of Indianapolis's last 25 games at home
Indianapolis is 4-1 ATS in its last 5 games when playing San Francisco
Indianapolis is 5-0 SU in its last 5 games when playing San Francisco

San Francisco 49ers

San Francisco is 5-1 ATS in its last 6 games
San Francisco is 5-1 SU in its last 6 games
The total has gone OVER in 4 of San Francisco's last 6 games
San Francisco is 6-2 ATS in its last 8 games on the road
San Francisco is 6-2 SU in its last 8 games on the road
The total has gone OVER in 5 of San Francisco's last 7 games on the road
San Francisco is 1-4 ATS in its last 5 games when playing Indianapolis
San Francisco is 0-5 SU in its last 5 games when playing Indianapolis

TEAM LAST 5 GAMES

San Francisco 49ers

DateOPP ScoreSU LineATS Result ORYOPY OTYDRY DPYDTY TOLoc
Dec 14, 2025 TEN 37-24 W -12.5/44.5 W/O 138 292 430 136 170 306 1 H
Nov 30, 2025 CLE 26-8 W -5.5/35 W/U 91 161 252 138 115 253 -2 A
Nov 24, 2025 CAR 20-9 W -7.5/49 W/U 147 193 340 69 161 230 1 H
Nov 16, 2025 ARI 41-22 W -3.5/48.5 W/O 95 186 281 36 452 488 -3 A
Nov 9, 2025 LAR 26-42 L 6/49.5 L/O 74 319 393 126 275 401 2 H

Indianapolis Colts

DateOPP ScoreSU LineATS Result ORYOPY OTYDRY DPYDTY TOLoc
Dec 14, 2025 SEA 16-18 L 13/41.5 W/U 97 118 215 50 264 314 1 A
Dec 7, 2025 JAC 19-36 L -2.5/45 L/O 89 196 285 103 247 350 2 A
Nov 30, 2025 HOU 16-20 L -3/44.5 L/U 86 195 281 108 256 364 -1 H
Nov 23, 2025 KC 20-23 L 4.5/49.5 W/U 74 181 255 148 346 494 -2 A
Nov 9, 2025 ATL 31-25 W -6.5/48.5 L/O 323 196 519 140 150 290 1 H