NFL MATCHUP REPORT

September 21, 2025, 4:25 | Levi's Stadium

Arizona Cardinals (2-0) VS San Francisco 49ers (2-0)

ODDS

Bet365
5Dimes
BOL
bodog
pin
Moneyline


110
-130
115
-135
110
-123
Spread


1.5 -105
-1.5 -115
2 -105
-2 -115
1 102
-1 -115
Total
o
u
o
u
43.5 o -115
43.5 u -105
44.5 o -105
44.5 u -115
43.5 o -116
43.5 u 101

RECENT FORM

NameRecord ATSOffense DefenseDiff ATS HomeATS Away OU RecordOU Home OU Away
Arizona 2-0 1-1 23.50 17.50 6.00 0-1 1-0 1-1 1-0 0-1
San Francisco 2-0 2-0 21.50 17.00 4.50 0-0 2-0 1-1 0-0 1-1

POWER STATS

Yards Per Point

NameOffense DefenseDifferential
ARI 12.11 19.06 -6.95
SF 16.93 15.79 1.14

Yards Per Pass

NameOffense DefenseDifferential
ARI 8.97 8.24 0.73
SF 10.23 8.1 2.13

Yards Per Rush

NameOffense DefenseDifferential
ARI 4.65 3.8 0.85
SF 3.16 3.66 -0.5

SMART CHART

ARI
NAME
SF
23.50
OFFENSE
21.50
17.50
DEFENSE
17.00
6
DIFFERENTIAL
4.5
170.50
PASSING YARDS
266.00
114.00
RUSH YARDS
98.00
255.50
PASSING YARDS ALLOWED
166.00
78.00
RUSHING YARDS ALLOWED
102.50
-0.5
TURNOVER DIFFERENTIAL
0

TEAM RECORDS

Arizona Cardinals

NameRecord HomeAway ATSATS Home ATS AwayOffense DefenseDiff
Overall 2-0 1-0 1-0 1-1 0-1 1-0 23.50 17.50 6.00
Last 3 2-0 1-0 1-0 1-1 0-1 1-0 23.50 17.50 6.00
vs Conf 2-0 1-0 1-0 1-1 0-1 1-0 0.00 0.00 0.00
vs Div 0-0 0-0 0-0 0-0 0-0 0-0 0 0 0

San Francisco 49ers

NameRecord HomeAway ATSATS Home ATS AwayOffense DefenseDiff
Overall 2-0 0-0 2-0 2-0 0-0 2-0 21.50 17.00 4.50
Last 3 2-0 0-0 2-0 2-0 0-0 2-0 21.50 17.00 4.50
vs Conf 2-0 0-0 2-0 2-0 0-0 2-0 8.50 6.50 2.00
vs Div 1-0 0-0 1-0 1-0 0-0 1-0 17.00 13.00 4.00

SUPERGRID

TitleStat RankStat Rank
Away Team Overall Scoring vs Home Team Overall Defense 23.50 11 17.00 8
Away Team Road Passing vs Home Team Home Passing Defense 130.00 24 0 0
Away Team Road Rushing vs Home Team Home Rushing Defense 146.00 5 0 0
Home Team Overall Scoring vs Away Team Overall Defense 21.50 19 17.50 10
Home Team Home Passing vs Away Team Road Passing Defense 0 0 208.00 14
Home Team Home Rushing vs Away Team Road Rushing Defense 0 0 107.00 15

HEAD TO HEAD SUMMARY

TeamRecord ATSOU ScoreRush YPRPA CPPY TYTO +/-
Arizona 5-5 5-5 6-4 22.30 134.40 4.78 36.40 68.68 226.90 361.30 1.30
San Francisco 5-5 5-5 6-4 27.00 142.80 5.29 30.00 65.33 233.00 375.80 1.10

HEAD TO HEAD DETAIL

DateAway HomeScore LineTotal OU ResultARY APYATY ATTHRY HPYHTY HTTAway Team Attempts Home Team AttemptsAway Team Completions Home Team Completions
Jan 5, 2025 SF ARI 24 - 47 -4.5 43 O 138 298 436 3 151 242 393 0 43 35 29 25
Oct 6, 2024 ARI SF 24 - 23 -7 49 U 169 189 358 1 153 231 384 3 30 35 19 19
Dec 17, 2023 SF ARI 45 - 29 12 48 O 144 262 406 0 234 202 436 2 28 39 18 26
Oct 1, 2023 ARI SF 16 - 35 -14.5 44 O 105 257 362 0 124 271 395 0 41 21 28 20
Jan 8, 2023 ARI SF 13 - 38 -14.5 40 O 61 194 255 4 169 142 311 0 27 20 20 15
Nov 21, 2022 SF ARI 38 - 10 9.5 43 O 159 228 387 0 67 247 314 2 29 44 20 30
Nov 7, 2021 ARI SF 31 - 17 -5.5 44.5 O 163 274 437 0 39 298 337 3 27 40 23 28
Oct 10, 2021 SF ARI 10 - 17 -6 48.5 U 152 186 338 1 94 210 304 1 29 31 15 22
Dec 26, 2020 SF ARI 20 - 12 -6 49 U 227 171 398 1 120 230 350 2 22 50 13 31
Sep 13, 2020 ARI SF 24 - 20 -7 48.5 U 180 224 404 1 123 243 366 0 40 33 26 19

BETTING ODDS TRENDS

San Francisco 49ers

San Francisco is 3-8 ATS in its last 11 games
San Francisco is 3-7 SU in its last 10 games
The total has gone OVER in 4 of San Francisco's last 5 games
San Francisco is 4-12 ATS in its last 16 games at home
San Francisco is 17-8 SU in its last 25 games at home
San Francisco is 2-5 SU in its last 7 games at home
San Francisco is 4-2 ATS in its last 6 games when playing Arizona
San Francisco is 5-9-1 ATS in its last 15 games when playing Arizona
San Francisco is 4-2 SU in its last 6 games when playing Arizona
The total has gone OVER in 6 of San Francisco's last 7 games when playing Arizona
San Francisco is 2-6-1 ATS in its last 9 games when playing at home against Arizona
San Francisco is 3-7 SU in its last 10 games when playing at home against Arizona
The total has gone OVER in 5 of San Francisco's last 7 games when playing at home against Arizona

Arizona Cardinals

Arizona is 9-4 ATS in its last 13 games
Arizona is 4-2 SU in its last 6 games
The total has gone OVER in 5 of Arizona's last 7 games
Arizona is 7-3 ATS in its last 10 games on the road
Arizona is 1-4 SU in its last 5 games on the road
The total has gone UNDER in 4 of Arizona's last 5 games on the road
Arizona is 2-4 ATS in its last 6 games when playing San Francisco
Arizona is 2-4 SU in its last 6 games when playing San Francisco
The total has gone OVER in 6 of Arizona's last 7 games when playing San Francisco
Arizona is 6-2-1 ATS in its last 9 games when playing on the road against San Francisco
Arizona is 7-3 SU in its last 10 games when playing on the road against San Francisco
The total has gone OVER in 5 of Arizona's last 7 games when playing on the road against San Francisco

TEAM LAST 5 GAMES

Arizona Cardinals

DateOPP ScoreSU LineATS Result ORYOPY OTYDRY DPYDTY TOLoc
Sep 14, 2025 CAR 27-22 W -7/45.5 L/O 82 211 293 49 303 352 -1 H
Sep 7, 2025 NO 20-13 W -5.5/44.5 W/U 146 130 276 107 208 315 0 A
Jan 5, 2025 SF 47-24 W -4.5/43 W/O 151 242 393 138 298 436 -3 H
Dec 28, 2024 LAR 9-13 L 6.5/48 W/U 113 283 396 68 189 257 2 A
Dec 22, 2024 CAR 30-36 L -5.5/47 L/O 206 176 382 243 149 392 2 A

San Francisco 49ers

DateOPP ScoreSU LineATS Result ORYOPY OTYDRY DPYDTY TOLoc
Sep 14, 2025 NO 26-21 W -3/40.5 W/O 77 267 344 121 186 307 0 A
Sep 7, 2025 SEA 17-13 W -2.5/43.5 W/U 119 265 384 84 146 230 0 A
Jan 5, 2025 ARI 24-47 L 4.5/43 L/O 138 298 436 151 242 393 3 A
Dec 30, 2024 DET 34-40 L 3.5/50.5 L/O 75 400 475 152 287 439 2 H
Dec 22, 2024 MIA 17-29 L -2/44 L/O 81 293 374 166 215 381 1 A