<p>After rallying to take the first two games of this four-game series, the White Sox shoot for more Wednesday night on the Southside, Michael Kopech gets the call for Chicago here against lefty Framber Valdez for Houston.</p>
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<h2>MLB Betting Odds</h2>
<p>Wednesday'sWednesday's baseball betting lines opened Houston and Valdez at around -150 over Chicago and Kopech, with an over/under of eight runs. Early betting action then dipped the Astros to -145.</p>
<p>Houston could also be found getting around +110, giving the run and a half on the run line.</p>
<h2>Astros-White Sox MLB Betting Preview</h2>
<p>Chicago scored four runs in the bottom of the eighth inning to win Monday'sMonday's series opener 4-2, then scored the last three runs of the game to win Tuesday 4-3. The White Sox won as +110 underdogs Monday, then as +125 dogs Tuesday against Justin Verlander.</p>
<p>With Tuesday's victory, Chicago now owns a five-game winning streak. At 61-56 overall, the White Sox now sit just one game behind first-place Cleveland in the AL Central, and they're one game behind Toronto in the battle for the No. 3 spot in the AL wild-card standings.</p>
<p>With Tuesday's loss, Houston is 5-3 over its last eight games. At 75-43 overall, the Astros lead the AL West by 11 games over second-place Seattle, and they're 2.5 games up on the Yankees in the race for the best record in the American League.</p>
<p>Chicago leads the season series with Houston three games to two.</p>
<h2>Wednesday'sWednesday's Pitching Match-Up</h2>
<p><a class="advblue" href="https://www.sportsbettingstats.com/mlb/pitcherlog/226581&quot; title="Michael Kopech Pitcher Game Logs">Kopech is 6/21 on quality starts</a> this season and going reasonably good as of late. Last Friday, he tossed six innings of no-hit ball against Detroit, with three walks and 11 strikeouts, in a 2-0 Chicago victory. And over his last four starts, he's held opponents to six runs and 17 hits through 21 2/3 innings.</p>
<p>The White Sox are 9-12 with Kopech this season, but that's probably three games worse than they should be, based on his performances.</p>
<p>In his lone career start against Houston, back in June of this season, Kopech allowed four runs and seven hits, including two home runs, through five innings of a 4-3 Chicago loss.</p>
<p><a class=:advblue" href="https://www.sportsbettingstats.com/mlb/pitcherlog/227319&quot; title="Framber Valdez Houston Astros Starting Pitcher">Valdez</a>, by our strict standards, is 16/22 on quality starts this year and two for his last three. Last Thursday, he held Texas scoreless on four hits through seven innings, with one walk against eight K'sK's, in a 7-3 Astros victory. And over his last three starts, he's held foes to six runs and 16 hits through 20 1/3 innings.</p>
<p>Houston is 14-8 with Valdez this season, and that's probably three games worse than they should be.</p>
<p>Over four career starts against the White Sox, three last year and one earlier this season, Valdez allowed 13 earned runs and 28 hits through 23 2/3 innings. The Astros won three of those four games.</p>
<h2>Splits With the Sticks </h2>
<p>Houston is batting .242 against right-handed pitching this season, with a .318 team OBP and a .415 team slugging percentage. The Astros have also scored at least six runs five times over their last eight games.</p>
<p>Chicago is slashing .273/.337/.423 against left-handed pitching.</p>
<h2>The Bullpens</h2>
<p>The White Sox bullpen owns a 3.92 ERA this season, along with a 1.31 WHIP.</p>
<p>The Astros pen owns an ML-best 2.90 ERA and a 1.16 WHIP.<br />
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<span style="font-size:16px; color:#008000;">Get more details:</span> <a href="https://www.sportsbettingstats.com/mlb/matchup/1599051">Houston at Chicago 8/17/22 Betting Stats</a>
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<h2>MLB Betting Trends</h2>
<p>Houston is 36-25 on the road this season and 46-32 against right-handed starters.</p>
<p>Chicago is 30-29 at home and 12-13 against left-handed starters.</p>
<h2>Totals Report </h2>
<ul>
<li>The Under is 70-45 in Astros games this season.</li>
<li>The Under is 58-52 in White Sox games.</li>
<li>The Under is 28-27 at Guaranteed Rate Field this season.</li>
<li>The Under is a combined 26-15 with Kopech and Valdez this season.</li>
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